A 65-year-old obese African American male patient presents to his HCP with crampy left lower quadrant pain, constipation, and fevers to 101˚ F. He has had multiple episodes like this one over the past 15 years and they always responded to bowel rest and oral antibiotics. He has refused to have the recommended colonoscopy even with his history of chronic inflammatory bowel disease (diverticulitis), sedentary lifestyle, and diet lacking in fiber. His paternal grandfather died of colon cancer back in the 1950s as well. He finally underwent colonoscopy after his acute diverticulitis resolved. Colonoscopy revealed multiple polyps that were retrieved, and the pathology was positive for adenocarcinoma of the colon.  Write 2-3 pages ·  Explain why you think the patient presented the symptoms described. ·  Identify the genes that may be associated with the development of the disease. ·  Explain the process of immunosuppression and the effect it has on body systems.

Adenocarcinoma | Nursing homework help

The patient presented symptoms of crampy left lower quadrant pain, constipation, and fevers to 101°F, which are commonly associated with inflammatory bowel disease (IBD), such as diverticulitis. The patient is a long-term sufferer of chronic diverticulitis, having experienced multiple episodes over the last 15 years. The patient’s symptoms responded well to both bowel rest, and oral antibiotics. This suggests that the condition may be chronic.

In addition to the patient’s history of IBD and sedentary lifestyle, his diet lacking in fiber and a family history of colon cancer also put him at risk for developing colon cancer. The patient’s paternal grandfather died of colon cancer in the 1950s, which suggests a genetic component to the development of the disease.

A number of genes are linked to the development and progression of colon cancer. These include APC, TP53, KRAS, and TP53. These genes may be affected by mutations that can cause colon cancer. This includes increased cell proliferation and loss of tumor suppressor function. The patient’s positive pathology for adenocarcinoma of the colon suggests the presence of these genetic mutations.

Immunosuppression refers to the suppression of the body’s immune system, which can have a negative effect on various body systems. The body’s inability to combat disease or infections can make people with immunosuppression more susceptible to infection and increase their risk of developing cancer. This could be a contributing factor to the patient’s development of colon cancer, as individuals with IBD are known to have a heightened risk of immunosuppression due to the chronic inflammation associated with the condition.

In conclusion, the patient’s symptoms of crampy left lower quadrant pain, constipation, and fevers are commonly associated with IBD, such as diverticulitis. The patient’s history of IBD, sedentary lifestyle, diet lacking in fiber, family history of colon cancer, and positive pathology for adenocarcinoma of the colon suggest a genetic component to the development of the disease. Immunosuppression, which is commonly associated with IBD, could also have contributed to the patient’s development of colon cancer by suppressing the body’s immune system and increasing the patient’s susceptibility to infections and disease.

 

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