Only clinical pharmacology
The chronic, painful autoimmune skin condition psoriasis can cause red patches and scaly areas on the skin. Psoriasis treatment depends on its severity and may include topical or systemic medications. For mild-to-moderate psoriasis, topical corticosteroids are a good option. Phototherapy, biologics, and systemic immunosuppressants are preferred for moderate-to-severe psoriasis.
Pharmacokinetics refers to the absorption of topical corticosteroids through the skin into the bloodstream. From there, they are metabolized by the liver and expelled in the urine. These drugs have anti-inflammatory, immunosuppressive and reduce itching. The skin side effects that can be caused by topical corticosteroids, such as stretch marks and skin thinning or loss of elasticity to infection, are known as localized corticosteroids. Monitoring for any side effects of topical corticosteroids is crucial.
Topical corticosteroids can be used in conjunction with other medication. These drugs are applied directly on the skin. You should exercise caution when you combine topical corticosteroids and other topical medication, because this could increase side effect risk. Patients should be educated about proper use, side effects and how to adhere to prescribed treatments.
Topical corticosteroids can be chosen based on the potency of each one. This ranges from very low to extremely high. Some corticosteroids are effective in mild cases of psoriasis, but high potency may be required for severe or moderate cases. How severe the condition is will determine the formulation. Creams/ointments have a thicker, more powerful formula than lotions or gels. They are suitable for those with thick plaques and dry skin.
When treating psoriasis, it is important to consider the life span. Because of their thin skin, and the increased chance of side effect and irritations, patients with psoriasis may need to use lower amounts of topical corticosteroids. These drugs can cause systemic side effects in pregnant and nursing women.
Psoriasis can be treated with a wide range of treatments, including topical or systemic. For mild-to-moderate cases, topical corticosteroids may be the most effective. To ensure safe and effective medication use, it is important to understand the pharmacokinetics, dynamics and monitor for side effects. Selection of topical corticosteroids should take into consideration the extent and severity of the psoriasis. Also, it must be considered the lifespan. For optimal patient outcomes, it is important to follow evidence-based guidelines.